Does Semaglutide Cause Acne? | Risks, Statistics, and Facts

Semaglutide, marketed under brand names like Ozempic and Rybelsus, is a popular medication for managing type 2 diabetes and aiding in weight loss. As its use becomes more widespread, questions about its potential side effects, including acne, have surfaced. In this article, we will find whether semaglutide can cause acne, supported by updated statistics and facts. 

Key Points

  • Clinical Evidence: Current clinical trials do not indicate a direct link between semaglutide and acne as a common side effect.
  • Hormonal Changes: Semaglutide's effect on insulin and blood sugar regulation might indirectly influence hormonal balance, potentially affecting skin health.
  • Lifestyle Factors: Weight loss and dietary changes associated with semaglutide use could impact skin condition, including acne.

What is Semaglutide?

Semaglutide works by mimicking the effects of the GLP-1 hormone, which helps regulate blood sugar levels, promote insulin secretion, and slow gastric emptying. This makes semaglutide effective in controlling type 2 diabetes and supporting weight loss. As more people use semaglutide, its potential side effects, such as acne, become a point of interest.

Understanding Acne

Acne is a common skin condition characterized by pimples, blackheads, and cysts, primarily occurring on the face, back, and shoulders. It results from clogged hair follicles due to oil and dead skin cells. Factors contributing to acne include hormonal changes, diet, stress, and certain medications.

The Link Between Semaglutide and Acne

Clinical Evidence

Clinical studies on semaglutide, including the SUSTAIN and STEP trials, have primarily focused on its effectiveness in managing diabetes and promoting weight loss. These studies have identified gastrointestinal issues as common side effects but have not highlighted acne as a prevalent concern. However, this does not entirely rule out the possibility of a connection, as individual responses to medications can vary.

Hormonal Changes

Semaglutide affects insulin regulation and blood sugar levels, which can influence hormonal balance. Hormonal changes are a well-known factor in the development of acne. For instance, increased insulin levels can stimulate the production of androgens, which in turn can increase sebum production and potentially lead to acne. Although not a direct cause, these hormonal shifts might indirectly impact skin health in some individuals.

Lifestyle Factors

  • Weight Loss:
    One of the primary benefits of semaglutide is weight loss. Significant weight loss can lead to changes in the body’s hormone levels and metabolism, which might affect skin condition. Rapid weight loss, in particular, can sometimes cause temporary imbalances that might manifest as acne.
  • Dietary Changes:
    Patients on semaglutide often adopt new dietary habits to support their weight loss goals. Dietary changes, especially those involving reduced carbohydrate intake and increased protein consumption, can influence skin health. Some individuals might experience improvements in acne, while others might see a temporary worsening of their condition due to changes in nutrient intake and hormone levels.

Statistics and Facts

Understanding the broader context of acne and semaglutide can provide valuable insights. Here are some interesting and relevant facts:

Acne Statistics

  • Prevalence:
    Acne affects approximately 85% of people between the ages of 12 and 24 at some point in their lives. It is one of the most common skin conditions globally. 
  • Adult Acne:
    While commonly associated with adolescence, acne can persist into adulthood. Adult acne affects up to 15% of women and 5% of men over the age of 25.
  • Hormonal Influence:
    Hormonal fluctuations during puberty, menstruation, pregnancy, and menopause can significantly influence acne development. This is due to increased androgen levels, which stimulate sebum production.

Facts About Semaglutide


Semaglutide is primarily used to manage type 2 diabetes and has been approved for weight management in certain patients. It helps lower blood sugar levels by enhancing insulin secretion and reducing glucose production in the liver.

Weight Loss

Clinical trials have shown that patients using semaglutide can lose an average of 10-15% of their body weight. This weight loss contributes to better overall health and can reduce the risk of other complications associated with obesity.

Side Effects

The most common side effects of semaglutide include gastrointestinal issues such as nausea, vomiting, and diarrhea. These are generally mild and tend to decrease over time as the body adjusts to the medication.

Practical Tips for Semaglutide Users

If you are taking semaglutide or considering it, here are some practical tips to help mitigate any potential risks related to acne:

Monitor Skin Changes

Keep an eye on any changes in your skin condition and report significant changes to your healthcare provider. Early intervention can help manage acne effectively.

Maintain a Skincare Routine

Establish a consistent skincare routine that includes cleansing, moisturizing, and using non-comedogenic products to prevent clogged pores and acne.

Balanced Diet

Adopt a balanced diet that includes plenty of fruits, vegetables, and whole grains. Avoid excessive intake of high-glycemic foods that can spike insulin levels and potentially worsen acne.


Drink plenty of water to keep your skin hydrated and support overall health. Proper hydration can help maintain skin elasticity and prevent clogged pores.


While there is no direct evidence linking semaglutide to the onset of acne, certain indirect factors such as hormonal changes, weight loss, and dietary adjustments can potentially influence skin health. Patients using semaglutide should focus on maintaining a balanced diet, consistent skincare routine, and staying hydrated to mitigate these risks. Always consult with healthcare providers for personalized advice and management strategies to ensure the safe and effective use of semaglutide.

By staying informed and proactive, you can safely manage your health while reaping the benefits of treatments like semaglutide. If you have specific concerns or experience significant skin changes, seek medical advice promptly. A balanced approach and open communication with your healthcare provider can help you navigate the complexities of managing your health with confidence.

About the author 

James Carter

I am James Carter, founder of Wellness for Youth. My journey in the health industry spans over 20 years, during which I have specialized in health, personal training, wellness and supplementation. I am passionate about promoting holistic wellness and better health practices. My mission with this platform is to deliver practical, scientifically grounded resources that cater to the diverse needs of our community, ensuring that everyone can achieve optimal health and wellness.

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